Breast Molecular Classifications

Receptors

Breast cancer cell receptors carry important prognostic information. The main receptors identified are estrogen receptors (ER), progesterone receptors (PR), and HER2/neu (HER2). Combinations of these receptors have been categorized by classes:

ClassCharacteristics
Luminal AER positive, PR positive, HER2 negative
Luminal BER or PR positive, HER2 negative
Luminal HER2ER or PR positive, HER positive
HER2ER and PR negative, HER2 positive
TNBC/BasalarER negative, PR negative, HER2 negative

Epidemiology

Pathology

Natural History

Clinical Workup and Evaluation

General Management and Treatment

Radiation Therapy Treatment Planning And Techniques

Outcomes, Patterns of Failure, Prognostic Indicators

Side Effects and Complications of Treatment